The most downloaded articles from Stem Cell Research in the last 90 days. Scientists warned the ‘devastating decision’ will stop pioneering treatments for degenerative diseases such as Alzheimer’s and Parkinson’s being developed in the UK, with potentially catastrophic consequences for the multi-million pound biotechnology industry. The decision follows a case brought by Greenpeace in Germany against Professor Oliver Brüstle (pictured) at the University of Bonn. He filed a patent with the German government in 1997 to convert embryonic stem cells into nerve cells to help patients with Parkinson's disease The resulting 10-page judgement prohibits patenting any process which involves removing a stem cell from and then destroying a ‘human embryo’ – defined as anything ‘capable of commencing the process of development of a human being.’It states: ‘Patents may not be granted for inventions whose commercial exploitation would be contrary to morality... In particular patents shall not be awarded for uses of human embryos for industrial or commercial purpose.’ However, scientists say stem cells taken from embryos in their early stages are crucial in developing life-saving treatments because they can turn into any cell type found in the body and so can be used to repair diseased and defective tissue. ‘I have just won an international prize from the New York Stem Cell Foundation for translating stem cell research into clinical practice, yet I find now that Europe, the continent in which I am doing this research, is basically calling me immoral’A trial of a stem cell treatment for blindness in young people – the first of its kind in Europe – has just begun at Moorfields Eye Hospital in London, with investment from an American biotechology firm.‘I have just won an international prize from the New York Stem Cell Foundation for translating stem cell research into clinical practice, yet I find now that Europe, the continent in which I am doing this research, is basically calling me immoral.’Professor Austin Smith, of Cambridge University’s Wellcome Trust for Stem Cell Research, said: ‘This unfortunate decision by the Court leaves scientists in a ridiculous position. We are funded to do research for the public good, yet prevented from taking our discoveries to the marketplace where they could be developed into new medicines.’She added: ‘We are a long way from a declaration on the inviolability of the human embryo but this is certainly a magnificent judgment in the right direction, and at the very least gives some added protection and respect to human life at its earliest stage.‘It is to be hoped that this will turn the attention of scientists once and for all away from the human embryo to concentrate on the innumerable ethically sourced neonatal and adult stem cell therapies which are already available. Embryonic stem cells are created during IVF treatment for infertile couples. Several eggs are fertilised as part of the process, but many will not be used.
Two Controversial Stem Cell Trials Could Harm Patients, Critics Say. Science Magazine – But is the idea underlying Macchiarini's work—”seeding” a scaffold with a patient's own stem cells, in hopes of regenerating a healthy, functional organ—still worth testing in patients? That's the question facing scientists in the United. Stem cell and cloning research using human cells remain controversial, even though it is nearly 20 years since Dolly the sheep became the first mammal to be cloned. One of the main reasons for this controversy…The 2012 Nobel Prize for Medicine and Physiology has been awarded to John Gurdon and Shinya Yamanaka, “for the discovery that mature cells can be reprogrammed to become pluripotent”.
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency. 1 Comment · image Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells. In work that brings researchers closer to the goal of precision medicine approaches to treating glaucoma and other neurodegenerative vision diseases, a new Indiana University-Purdue University Indianapolis (IUPUI) study has, for the first time, been able to identify a wide variety of previously u Researchers at Houston Methodist have used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain. Cells made by fusing a normal human muscle cell with a muscle cell from a person with Duchenne muscular dystrophy — a rare but fatal form of muscular dystrophy — were able to significantly improve muscle function when implanted into the muscles of a mouse model of the disease. Young, resting neural stem cells in the brains of mice store large clumps of proteins in specialized cellular trash compartments known as lysosomes, researchers at the Stanford University School of Medicine have found.
The Japanese stem cell scientist who was accused of misconduct by her own research institution apologized Wednesday for making careless mistakes but insisted that her STAP stem cells are real. Haruko Obokata told reporters at a news conference that she “produced the STAP cells successfully more than 200 times, and. Dear Student, The University is committed to a culture of academic engagement between students and faculty. Part of this commitment involves taking responsibility for attending your classes, labs, and exams, and informing your instructors when you cannot attend. Rutgers students are expected to attend all scheduled course meetings. University policy excuses absences due to religious observance or participation in Rutgers-approved activities, and permits students to make up work missed for these circumstances. If you will be absent from a class, lab, or exam for any reason, please report your absence (by clicking the button below) so we may inform your instructors and advisors. Please note: it is up to your instructors to determine how to handle your absence from classes, labs, or exams. It notifies your instructors, a courtesy that provides an opportunity for you to contact your instructor directly about missed work. In addition to reporting your absence here, we encourage you to contact your instructors directly. If you anticipate missing more than one week of classes for serious illness, confidential, or sensitive personal reasons, you should also consult with a New Brunswick Dean of Students , Newark Dean of Students or Camden Dean of Students who will help to verify your extended absences from classes.
Sep 15, 2014. Privately funded research at the time was unaffected and President Obama eased the restrictions in 2009. The article also referred imprecisely to the approach of the Michael J. Fox Foundation for Parkinson's Research toward stem cell research. While the majority of the foundation's current funding is for. When doctors give their patients a difficult diagnosis, whether it’s for a condition like cancer or a rarer disease for which there is no standard treatment, they often refer them to Food and Drug Administration (FDA) announced that the agency is targeting clinics that offer unproven stem cell therapies, calling such offices "unscrupulous clinics" selling "so-called cures." The FDA seized materials from...
Stem Cell Research is dedicated to. Track accepted paper. Once production of your article has. • Methods and reagents articles • Lab Resource Stem Cell. Human Stem Cell Research has been headline news since 1998 when embryonic stem cells were first scientifically isolated. Many claims were made for medical miracles that could be discovered through this research. Since then, newspaper and magazine articles either championed or vilified embryonic stem cell research. In reality, there exists a more general field of stem cell research than just embryonic stem cell research. Another, and possibly a more important area, is the research into the usefulness of adult stem cells. Adult stem cells can be harvested without destroying life as we shall see is not the case with embryonic stem cells. Adult stem cell research is not as well-publicized and is not as well-known by the general public as embryonic stem cell research. This situation (as seen and reported by the media) may be due to the less radical cell harvesting methods for adult stem cells than the sensationalism and controversy which surround the embryonic stem cell harvesting methods.
Organoids” derived from stem cells help show how embryos develop and why adults get certain diseases. They may even be used as treatments. Stress test. Science in Japan Stress test. Aug 7th 2014, from Print edition. After a scandal, a renowned stem-cell scientist commits suicide. Prometheus unbound. Stem-cell. On the cusp of a new era in stem cell science, Democratic heavyweights are pushing to install the outgoing California Democratic Party chief in a leadership post at the state's $3-billion research program. Dianne Feinstein and Barbara Boxer of California and Sen. Scientists reported Thursday that for the first time they have made human embryonic stem cells without destroying embryos, a development that the government's top stem cell official said would make the controversial research eligible for federal funding. Art Torres, who served two decades as a state lawmaker before assuming the party chairmanship a dozen years ago, is being backed by House Speaker Nancy Pelosi, U. Story Landis, who chairs the National Institute of Health's stem cell task force, said that with certain safeguards, the new method appeared to comply with federal restrictions that have largely cut scientists off from the $28 billion the government spends on medical research each year. Researchers have reprogrammed cells inside living mice -- and have discovered that the pluripotent stem cells created in the process are even more flexible than those derived from embryos or grown in laboratory dishes. Someday the achievement might help scientists devise ways to treat human disease by directly regenerating tissues within human patients, said Manuel Serrano, an investigator at the Spanish National Cancer Research Center in Madrid and senior author of a study ( abstract here )For a $330,000 burger, taste testers thought the flavor fell a little flat. The hefty price tag, however, wasn't for some fancy, rare cut of meat.
Jan 16, 2017. The breakthrough sidestepped the embryo controversy, offering researchers an unlimited supply of stem cells. Dr. Yamanaka shared. A version of this article appears in print on January 17, 2017, on Page D7 of the New York edition with the headline The Stem-Cell Revolution Is Coming — Albeit Slowly. ) that using the cells to replace eye tissue damaged by age-related macular degeneration (AMD) did not improve a patient’s vision, but did halt disease progression. They had described the outcome at conferences, but publication of the details is an encouraging milestone for other groups gearing up to treat diseased or damaged organs with the versatile replacement cells, which are derived from mature tissues. This initial success “is pretty momentous,” says Alan Trounson, a stem cell scientist at the Hudson Institute of Medical Research in Melbourne, Australia. But the broader picture for i PS therapies is mixed, as researchers have retreated from their initial hopes of creating custommade stem cells from each patient’s tissue. That strategy might have ensured that recipients’ immune systems would accept the new cells.
Mar 15, 2017. It's official The first use of induced pluripotent stem iPS cells in a human has proved safe, if not clearly effective. Japanese researchers reported in this week's issue of The New England Journal of Medicine NEJM that using the cells to replace eye tissue damaged by age-related macular degeneration. Recent medical developments, gene splicing and treating paralysis by means of embryonic stems cells, have been heralded by an uncritical public as great advances in reducing human suffering. In both cases, we have forgotten something important: an embryonic person has been sacrificed in the process. Tad Pacholcyzk, bioethicist from the National Catholic Bioethics Center, recently wrote an eloquent article about these . Perhaps the problem is not just that they are expendable, but invisible. Even when presented with the information that treatment requires embryonic stem cells, far too many people fail to make the connection between that term and the reality of a person. The embryo is not merely expendable: he is not even recognized as present. The great wonder of medical advancement blinds us of the reality of the tiny person being sacrificed to make it possible. In an Internet discussion, I remarked that, in the case of embryonic stem cell research, a human person had to die in the process. Even in that thread, populated largely by Christians, many of whom are Catholic, the response was swift and strong in defense of new advancements and in derision of my comment.
Apr 10, 2013. Many of these researchers adopted Yamanaka's procedure to create their own induced pluripotent stem cells. For the first time, researchers had a tool that could allow them to make stem cells from people with rare genetic diseases. This helps scientists learn what makes certain cell types die. Experts can. Scientific research into curing HIV infection has expanded significantly in recent years, gaining a much higher profile in the press. Unfortunately, media coverage of cure research can be inaccurate and tends to overhype preliminary results. The purpose of this page is to provide TAG’s perspective on cure research in the news, with the aim of placing stories in context and addressing any inaccuracies. A glossary of terms used in HIV cure research is TAG's commentary: This story relates to a published case report about an HIV individual who received a new type of immunotherapy to treat his lung cancer. Because there is just one person involved, no conclusions can be drawn from the results - this important point is made by several scienists who are quoted in the media coverage. The individual in question is reported to have experienced a reduction in levels of HIV DNA in their bloodstream when they were measured 120 days after starting the immunotherapy. HIV DNA levels are a rough measurement of the HIV reservoir that persists despite antiretroviral therapy (ART). The HIV reservoir is considered the major barrier to achieving a cure, and there is a lot of research into approaches that might reduce the reservoir size.
Burbank Leader Opinion · In Theory Scientists may soon be able to engineer organs. What does religion have to say about that? Apr 11, 2017. California's stem cell program ponders a future of new challenges and old promises. Column. California's stem cell program ponders a future of new challenges and old promises. A new study from Lund University in Sweden shows that the behaviour of stem cells in plants and animals is surprisingly similar. The researchers were able to produce mathematical equations that reveal very small differences in the behaviour of the proteins. The results can hopefully be used in stem cell research involving humans.“The plant and animal kingdoms were separated through evolution more than 1.6 billion years ago. It is surprising that the interactions between the handful of key genes that control the fate of each stem cell are so similar in both cases”, says Carsten Peterson, professor at the Faculty of Science at Lund University. Carsten Peterson is one of the researchers behind the recent study on differences and similarities between animal and plant stem cells. With a background in theoretical physics, he and his colleagues have tackled the stem cells from a different perspective, which proved successful. By formulating mathematical equations, the researchers have performed a detailed study of the proteins that are central to the stem cells in mammals and plants. The proteins are linked to the genes that control the stem cells.
Browse Embryonic stem cells news, research and analysis from The Conversation. Chih-Chien Hsu | Huai-En Lu | Jen-Hua Chuang | Yu-Ling Ko | Yi-Ching Tsai | Hsiao-Yun Tai | Aliaksandr A. Yarmishyn | De-Kuang Hwang | Mong-Lien Wang | Yi-Ping Yang | Shih-Jen Chen | Chi-Hsien Peng | Shih-Hwa Chiou | Tai-Chi Lin Eris Bidollari | Giovannina Rotundo | Daniela Ferrari | Ornella Candido | Laura Bernardini | Federica Consoli | Alessandro De Luca | Iolanda Santimone | Giuseppe Lamorte | Andrea Ilari | Ferdinando Squitieri | Angelo Luigi Vescovi | Jessica Rosati Filomena Altieri | Elisa Maria Turco | Ersilia Vinci | Barbara Torres | Daniela Ferrari | Antonella De Jaco | Gianluigi Mazzoccoli | Giuseppe Lamorte | Annamaria Nardone | Matteo Della Monica | Laura Bernardini | Angelo Luigi Vescovi | Jessica Rosati Charline Jansch | Katharina Günther | Jonas Waider | Georg C.
Read a National Geographic magazine article about stem cell research and get information, facts, and more about embryonic stem cells. When scientists first created induced pluripotent stem cells (i PS cells) three years ago, they were hailed as a game-changing advance for medicine: Scientists hoped the engineered cells could duplicate the talents of embryonic stem cells, which can develop into any kind of cell in the body, while avoiding the destruction of embryos. Advanced Cell Technologies, the Massachusetts lab led by stem cell guru Robert Lanza, released a study of 25 embryonic lines and eight i PS lines in the journal Stem Cells last week. cell labs suggests that i PS cells, at least right now, have serious problems keeping them from reaching their potential. At first they found that human i PS cells could indeed generate blood vessel, blood precursor and retinal cells with characteristics similar to ones derived from embryonic stem cells, albeit with significantly reduced efficiency. But the blood and retinal cells showed much higher rates of cell death and premature aging. According to Lanza, there was a 1,000- to 5,000-fold differenceâ€ between the i PS cellsâ€™ ability to keep growing and dividing and the true embryonic cellsâ€™ ability, he says. â€œIn terms of whether you can use the cells therapeutically or to study disease, thatâ€™s the difference between getting the study to work and being dead in the waterâ€ So whatâ€™s the problem? Lanza suspects that it comes from the use of viruses to insert genes into cells and make them revert to that pluripotent state. But, Newsweek reports, there are other ways to create i PS that show promise for creating healthier cells.
A hub covering the latest stem cell research and news from bench science and clinical applications, and forum for research labs and societies worldwide. The Foundation is committed to the Pursuit of International Cooperation, Collaboration and Excellence in the Stem Cell Field. The Irish Stem Cell Foundation is a non-profit organization. It was established in Dublin in October 2009, and is composed of doctors, researchers, patient advocates, science communicators, solicitors, teachers and students. The Foundation's Objectives are to: Accelerate Stem Cell Research to cure major illnesses and injury. Provide a focus on education in all areas of stem cell research and therapy. The Chief Medical Officer of the Foundation is Professor Orla Hardiman. The Foundation has intensely engaged the international and domestic media on the topic of stem cell tourism, where patients are scammed by unregulated clinics making medically and scientifically unsubstantiated claims to patients over the internet. Such experimental protocols endanger patients' lives and harm the reputation of legitimate stem cell research and clinical trials (which are tightly regulated).
Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter. 1 Comment. Researchers identify transcription factors and environmental conditions necessary to reprogram human and mouse cells into cells that function like hematopoietic stem cells. van Laake | Robert Passier | Jantine Monshouwer-Kloots | Arie J. Lips | Christian Freund | Krista den Ouden | Dorien Ward-van Oostwaard | Jeroen Korving | Leon G. Mummery Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury Fatih Arslan | Ruenn Chai Lai | Mirjam B. Doevendans | Gerard Pasterkamp | Sai Kiang Lim | Dominique P. Rösingh | Kinga Molnár | Lajos László | Tamás Bellák | Annamária Téglási | Krisztina Pesti | Arpad Mike | Phetcharat Phanthong | Orsolya Bíró | Vanessa Hall | Narisorn Kitiyanant | Karl-Heinz Krause | Julianna Kobolák | András Dinnyés Ruenn Chai Lai | Fatih Arslan | May May Lee | Newman Siu Kwan Sze | Andre Choo | Tian Sheng Chen | Manuel Salto-Tellez | Leo Timmers | Chuen Neng Lee | Reida Menshawe El Oakley | Gerard Pasterkamp | Dominique P.
The latest stem cell research research from prestigious universities and journals throughout the world. While some researchers still claim that embryonic stem cells (ESCs) offer the best hope for treating many debilitating diseases, there is now a great deal of evidence contrary to that theory. Use of stem cells obtained by destroying human embryos is not only unethical but presents many practical obstacles as well. "Major roadblocks remain before human embryonic stem cells could be transplanted into humans to cure diseases or replace injured body parts, a research pioneer said Thursday night. University of Wisconsin scientist James Thomson said obstacles include learning how to grow the cells into all types of organs and tissue and then making sure cancer and other defects are not introduced during the transplantation. 'I don't want to sound too pessimistic because this is all doable, but it's going to be very hard,' Thomson told the Wisconsin Newspaper Association's annual convention at the Kalahari Resort in this Wisconsin Dells town. 'Ultimately, those transplation therapies should work but it's likely to take a long time.'.... *** From a major foundation promoting research in pancreatic islet cells and other avenues for curing juvenile diabetes: "Is the use of embryonic stem cells close to being used to provide a supply of islet cells for transplantation into humans? The field of embryonic stem cells faces enormous hurtles to overcome before these cells can be used in humans. Thomson cautioned such breakthroughs are likely decades away." Online, posted on Feb. The two key challenges to overcome are making the stem cells differentiate into specific viable cells consistently, and controlling against unchecked cell division once transplanted. 8, 2007, "Although embryonic stem cells have the broadest differentiation potential, their use for cellular therapeutics is excluded for several reasons: the uncontrollable development of teratomas in a syngeneic transplantation model, imprinting-related developmental abnormalities, and ethical issues." -Gesine Kögler et al., "A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential," , Vol. Solid data of stable, functioning islet cells from embryonic stems cells in animals has not been seen." -"Q & A," Autoimmune Disease Research Foundation, & A.htm, accessed July 2004.
A free collection of articles about stem cells published in The New York Times. Paolo Macchiarini is leaving Russia, his research and surgery stint there is over. The fallen star surgeon was able to find a professorship with the Federal University of Kazan (KFU), after his plastic trachea transplants at the Kuban State Medical University in Krasnodar left 3 patients dead, and one with a lucky escape (see details here). His new research focus was on artificial oesophagus, which he apparently already started to test on hapless baboons. In March 2017, the Russian state decided that Macchiarini’s federal grant on oesophagus research will not be renewed, the Kazan University announced in regard to their professor’s further employment to follow the instructions from the Russian Science Foundation. The professorship contract expires by December 2017.
Read about today's stem cell research including novel stem cell technology and advances in understanding cancer stem cells. DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), they are one of the four major types of macromolecules that are essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix. The two DNA strands are called polynucleotides since they are composed of simpler monomer units called nucleotides. Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a sugar called deoxyribose, and a phosphate group.
Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes. With more than two million page views and more than 4,500 items, this blog provides news and commentary on public policy, business and economic issues related to the $3 billion California stem cell agency, officially known as the California Institute for Regenerative Medicine(CIRM). David Jensen, a retired California newsman, has published this blog since January 2005. California's $3 billion stem cell agency took its message of hope for possible therapies to Riverside this week, part of its continuing outreach program that is increasingly taking on additional importance. Because the agency is scheduled to run out of cash for new awards by the end of next year. It is hoping to raise $220 million to stave off its demise until November 2020 when the plan is to ask state voters to approve an additional $5 billion in funding. "It was a packed event, with an overflow group watching on monitors outside the auditorium. The questions asked afterwards didn’t just focus on the research being done, but on research that still needs to be done. "One patient advocate couple asked about clinics offering stem cell therapies for Parkinson’s disease, wondering if the therapies were worth spending more than $10,000 on.... "The visit was a strong reminder that there is exciting stem cell research taking place all over California and that the Inland Empire is a key player in that research, working on projects that could one day have a huge impact in changing people’s lives, even saving people’s lives." The stem cell agency, formally known as the California Institute for Regenerative Medicine (CIRM), is not exactly a household word among most Californians. Events such as the one in Riverside help to spread the word about its activities to voters who might be considering another funding initiative for the agency.
Charlatans threaten stem cell research with unproven cures. Stem cells help some men with erectile dysfunction after prostate surgery. digital newspaper archive A comprehensive document for the benefit of people interested in living very long healthy lives and who are willing to adapt emerging knowledge personally to do so.  FORWARD VIEW FROM JULY 2014 More than six years have elapsed from drafting the initial version of this treatise and despite many updates parts of it show age. Many topics and insights I would now include are missing. The original concept of this treatise was to look at the main existing scientific theories of aging, see what they have in common, see what each has to say about steps that could be taken to halt or delay aging, and combine these steps into an overall "antiaging firewall." That firewall would define practical lifestyle and dietary interventions that would create long-lasting health and longevity based on the known science. This was a good concept and it has personally served me well. However, my thinking about health and aging has continued to become more sophisticated and nuanced and the science itself has also evolved significantly during the period.